Skin penetration and tissue permeation after topical administration of diclofenac
نویسندگان
چکیده
منابع مشابه
Favourable dermal penetration of diclofenac after administration to the skin using a novel spray gel formulation.
AIMS The study was designed to evaluate the relative bioavailability of diclofenac in plasma, subcutaneous adipose and skeletal muscle tissue after repeated topical administration using MIKA Diclofenac Spray Gel (4%), a novel formulation, and after oral dosing using VOLTAREN 50 mg enteric coated tablets. METHODS Diclofenac (48 mg) was administered topically three times daily for 3 days onto a...
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The current study was designed to develop a topical gel formulation for improved skin penetration of lornoxicam (LOR) for enhancement of its analgesic activity. Moreover, the effect of different penetration enhancers on LOR was studied. The LOR gel formulations were prepared by using hydroxylpropyl methylcellulose (HPMC) and carbopol. The carbopol gels in presence of propylene glycol (PG) and e...
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The pharmacokinetic disposition of telavancin administered 7.5 mg/kg of body weight every 24 h was determined in plasma and skin blister fluid. The mean penetration of telavancin into blister fluid was 40%. This study reveals that adequate concentrations are achieved in both plasma and blister fluid for pathogens frequently implicated in skin and soft tissue infections.
متن کاملAqueous and vitreous penetration of levofloxacin after topical and/or oral administration.
PURPOSE To investigate the aqueous and vitreous penetration of levofloxacin, the drug was administered topically and/or orally to patients undergoing vitrectomy. METHODS Thirty-six patients undergoing initial vitrectomy with phacoemulsification and aspiration (PEA) were enrolled, and were divided randomly into three groups. Group 1 was treated with topical application of levofloxacin (three t...
متن کاملFormulations, Release and Skin Penetration of Topical Anesthetics
Welin-Berger, K., 2001. Formulations, Release and Skin Penetration of Topical Anesthetics. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 258. 53 pp. Uppsala. ISBN 91-554-5115-2. This thesis describes certain critical aspects of the development of semisolid topical anesthetic formulations requiring a fast onset of action. Furthermor...
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ژورنال
عنوان ژورنال: Current Medical Research and Opinion
سال: 2017
ISSN: 0300-7995,1473-4877
DOI: 10.1080/03007995.2017.1352497